https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Evaluating family planning organizations under China's two-child policy in Shandong Province https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45000 Wed 26 Oct 2022 09:35:41 AEDT ]]> Efficacy of GP referral of insufficiently active patients for expert physical activity counseling: protocol for a pragmatic randomized trial (the NewCOACH trial) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16751 Wed 11 Apr 2018 16:36:30 AEST ]]> MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15166 V600E melanoma cells to B-RAF inhibitors. Experimental Design: B-RAFV600E melanoma cells were exposed to the B-RAF inhibitor PLX4720 for prolonged periods to select for cells resistant to apoptosis induced by the inhibitor. The resultant cells were analyzed for activation of extracellular signal regulated kinase (ERK), MAP/ERK kinase (MEK), and Akt, and related signals. Their roles in survival of the cells were also examined. Results: B-RAFV600E melanoma cells selected for resistant to PLX4720-induced apoptosis retained the V600E mutation in B-RAF, and proliferated steadily in the presence of the inhibitor, albeit with slow growth rate. These cells displayed high levels of ERK activation, that is, at least in part, independent of the conventional RAF/MEK/ERK pathway, as MEK activation was low and inhibition of MEK did not significantly block activation of ERK. In contrast, extracellular signals appeared involved. This was associated with elevated activation of the phosphoinositide 3-kinase (PI3k)/Akt pathway and could be inhibited by serum starvation and inhibition of PI3k/Akt. Inhibition of MEK did not impact on survival of these cells, whereas serum starvation, inhibition of PI3K/Akt, and inhibition of ERK1/2 reduced their viability. Conclusions: These results indicate that sensitivity to induction of apoptosis may be a major determinant of long-term responses of B-RAFV600E melanomas to specific inhibitors and suggest that rebound melanoma growth after initial treatment with the inhibitors may not be responsive to MEK inhibitors, but may be susceptible to inhibition of the PI3k/Akt pathway.]]> Wed 11 Apr 2018 16:15:39 AEST ]]> 2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6913 Wed 11 Apr 2018 15:38:21 AEST ]]> Haze attitudes and the willingness to pay for haze improvement: evidence from four cities in Shandong province, China https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35028 Wed 06 Apr 2022 13:59:29 AEST ]]> Cluster lag synchronization of delayed heterogeneous complex dynamical networks via intermittent pinning control https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48111 Tue 28 Feb 2023 14:38:09 AEDT ]]> Disease causing poverty: adapting the Onyx and Bullen social capital measurement tool for China https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39714 Thu 23 Mar 2023 11:15:00 AEDT ]]> Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7006 Sat 24 Mar 2018 08:37:51 AEDT ]]> Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7007 Sat 24 Mar 2018 08:37:51 AEDT ]]> TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9621 Sat 24 Mar 2018 08:35:27 AEDT ]]> Contrasting effects of Nutlin-3 on TRAIL- and Docetaxel-induced Apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10447 Sat 24 Mar 2018 08:08:03 AEDT ]]> A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18344 Sat 24 Mar 2018 07:52:35 AEDT ]]> Referral for expert physical activity counseling: a pragmatic RCT https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31054 Sat 24 Mar 2018 07:25:47 AEDT ]]> Interaction between tetramethylcucurbit[6]uril and some pyridine derivates https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3187 Sat 24 Mar 2018 07:21:56 AEDT ]]>